Quiz SP 22

Please answer the following six questions based on the information provided in the pre-reading documents. To complete and receive your CPD points, you must achieve a 75% pass rate. You’ll have the option to retake the quiz at the end.

The first three questions relate to paper 1 and the second three questions relate to paper 2.

Paper 1
Kahleova H, Petersen KF, Shulman GI, et al. Effect of a Low-Fat Vegan Diet on Body Weight, Insulin Sensitivity, Postprandial Metabolism, and Intramyocellular and Hepatocellular Lipid Levels in Overweight Adults: A Randomized Clinical Trial. JAMA Network Open. 2020;3(11):e2025454.

(16‑week RCT, n=244; low‑fat vegan diet ~10% fat, high in whole grains, legumes, vegetables, fruits vs no diet change.)

Paper 2
Sarabhai T, Kahl S, Szendroedi J, et al. Monounsaturated fat rapidly induces hepatic gluconeogenesis and whole‑body insulin resistance. JCI Insight. 2020;5(10):e134520.

(16 healthy adults; randomised placebo‑controlled crossover; single MUFA‑rich canola oil drink (~1.18 g/kg) vs water.)

1. In the 16-week trial of a low-fat vegan diet in overweight adults, which outcome best describes the main metabolic effect?
2. Which dietary pattern most closely matches the intervention used in the trial?
3. Which change is most likely to have contributed to the improvement in insulin sensitivity seen in the low-fat vegan group?
4. In healthy lean adults, what was the effect of a single MUFA-rich canola oil load on hepatic and whole-body insulin sensitivity?
4. Which finding best describes the metabolic response to the canola oil drink in the study?
6. What is the key clinical takeaway from this study of a single MUFA-rich fat load?